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Basic Science Symposium – Mechanisms of Alcohol-Associated Liver Disease: Molecular, Cellular and Systemic Crosstalk

Saturday, November 14
 
9:00 AM
 - 
5:30 PM

Speakers

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About the Session

Part I: 9:00 am – Noon | Part II: 2:00 pm – 4:30 pm | Audience Q&A: 4:30 pm – 5:30 pm

Program Chairs: Laura Nagy, PhD, FAASLD; Wen-Xing Ding, MD, PhD, FAASLD; Vijay Shah, MD, FAASLD

At the Basic Science Symposium, basic and clinical investigators will summarize the newest research in the molecular and cellular mechanisms of alcohol-induced liver disease (ALD). Topics include hot discoveries in organelle and protein damage, cross-talk of multiple organs and tissues, microbiota, cell-to-cell communication, and immune response in ALD pathogenesis. Junior investigators and pre- and post-doctoral trainees are encouraged to attend.

Program Agenda

Part I

9:00 am – Noon

Session I: Organelle Damage and Stress in ALD

  • Lipid Droplet Dynamics and Metabolism in ALD
  • Kupffer Cell ER Stress in ALD
  • Role of Immune Cell Autophagy and Lysosome in ALD5
  • Mitochondrial Dynamics and Homeostasis in ALD

Session II: Microbiota and Secretokines in ALD

  • FGF21 in Hepatic Lipid Metabolism and ALD
  • Small-Molecule Production and Immune Modulation by the Microbiome
  • Gut Derived Metabolites and ALD
  • Exosomes and Metabolites in ALD
  • Intestine FGF19 and Adipokines in ALD

Learning Objectives:

  • Review cutting-edge approaches to assess cell death in vivo and in vitro.
  • Discuss the emerging role of non-apoptotic cell death in liver physiology and pathology.
  • Review molecular mechanisms regulating cell death in the liver.
  • Explain the generation of interest by junior investigators in studies of cell death in the liver.

Part II

2:00 pm – 4:30 pm

Session III: Innate Immunity and Inflammation in ALD

  • Role of Neutrophils in ALD
  • IL1 Receptor in ALD
  • Macrophage/Kupffer Cell Activation in ALD
  • Immune Cell Death in ALD

Session IV: Tissue Crosstalk in ALD

  • Adipose-liver Axis in ALD
  • Muscle-liver Axis in ALD
  • Intestine Goblet Cells and Intestine Regeneration in ALD
  • Closing Remarks [Translating the Basic Research: Update on Ongoing Clinical Studies in ALD]

Learning Objectives:

  • Review cutting-edge approaches to assess cell death in vivo and in vitro.
  • Discuss the emerging role of non-apoptotic cell death in liver physiology and pathology.
  • Review molecular mechanisms regulating cell death in the liver.
  • Explain the generation of interest by junior investigators in studies of cell death in the liver.

Audience Q&A

4:30 pm – 5:30 pm