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Basic Science Symposium – Mechanisms of Alcohol-Associated Liver Disease: Molecular, Cellular and Systemic Crosstalk

Saturday, November 14
9:00 AM
5:30 PM


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About the Session

Part I: 9:00 am – 11:30 | Part II: 2:00 pm – 3:30 pm | Audience Q&A: 4:30 pm – 5:30 pm
Program Chairs:
Laura Nagy, PhD, FAASLD; Wen-Xing Ding, MD, PhD,FAASLD; Vijay Shah, MD, FAASLD
Continuing Education Credits: Up to 5.75 CME Credits Offered | Up to 5.75 ABIM MOC Points Offered

The Basic Science Symposium explores basic and clinical aspects of molecular and cellular mechanisms of alcohol-associated liver disease (ALD), for which there is currently no effective therapy. Faculty will summarize research on the molecular and cellular mechanisms of alcohol-induced liver injury, including hot discoveries related to organelle and protein damage, organ/tissue cross-talk, microbiota and immune response in ALD pathogenesis.

Program Agenda

Part I

9:00 am – 11:30 pm
Session I: Organelle Damage and Stress in ALD

  • Welcome and Introductions; Laura Nagy
  • Lipid Droplet Dynamics and Metabolism in ALD; Mark McNiven
  • Kupffer Cell ER Stress in ALD; Yasuko Iwakiri
  • Role of Immune Cell Autophagy and Lysosome in ALD5; Steven Weinman
  • Mitochondrial Dynamics and Homeostasis in ALD; Wen-Xing Ding

Session II: Microbiota and Secretokines in ALD

  • Microbe and Host Metabolism and Genetics in ALD; J. Mark Brown
  • Gut Derived Metabolites and ALD; Bernd Schnabl
  • Exosomes and Metabolites in ALD; Vijay Shah
  • Mitochondrial dsRNA and TLR3 in ALD; Won-Il Jeong

Part II

2:00 pm – 3:30 pm
Session III: Innate Immunity and Inflammation in ALD

  • Role of Neutrophils in ALD; Bin Gao
  • IL1 Receptor in ALD; Gyongyi Szabo
  • Macrophage/Kupffer Cell Activation in ALD; Cynthia Ju
  • Immune Cells and ALD; Harmeet Malhi

Session IV: Tissue Crosstalk in ALD

  • Adipose-liver Axis in ALD; Laura Nagy
  • Muscle-liver Axis in ALD; Srinivasan Dasarathy
  • Intestine Goblet Cells and Intestine Regeneration in ALD; Ana Cristina Llorente Izquierdo
  • Closing Remarks: Translating the Basic Research: Update on Ongoing Clinical Studies in ALD; Suthat Liangsipukal

Audience Q&A (Live)

4:30 pm – 5:30 pm